… Another ubiquitin E3 ligase linking protein homeostasis and ageing is the quality control …
inates DAF-16, the worm FOXO, counteracting polyubiquitination by RLE-1 E3 ligase and its sub…

… remove ubiquitin conjugates (deubiquitylases), regulate the … to E3-ligases, catalyzing covalent
attachment of ubiquitin to … factor DAF-16 with the RING-finger E3-ubiquitin ligase RLE-1 […

… DAF-16 is SUMOylated, and that this modification represses the transcriptional activity of
DAF-16… that activation of SKN-1 negatively regulates DAF-16, which is in agreement with our …

… transcription factors consisting of DAF-16 in Caenorhabditis elegans, dFOXO in Drosophila
… The loss of RLE-1, an E3 ubiquitin ligase that catalyzes DAF-16 polyubiquitination, extends …

… be used as a biomarker of ageing and the ageing pigment lipofuscin is accumulated as a …
in life extension by regulating the entry of the transcription factor DAF-16 and heat shock factor-…

… E3 ubiquitin ligase, Regulation of Longevity by E3 (RLE-1) has previously been identified in
the modulation of aging by the ubiquitination of DAF-16 [… through monoubiquitination, where …

… with ageing and determined their expressions, including daf-16 (Fork-… gene of daf-16 and
regulates the expression of daf-16 by a … Sir-2.1 is a cofactor of daf-16 that can bind to daf-16 to …

… For instance, the E3 ubiquitin ligase CHIP regulates the levels of DAF-2 through its ubiquitination
… Downregulation of RLE-1 E3 ligases results in less polyubiquitination of DAF-16, and …

… of the modern society confronting aging. Although, … DAF-16 which is a homolog of FOXO
regulating stress response and life span. DAF-16 is a convergent transcription factor related to c…

… cardiac accumulation of polyubiquitinated proteins and abnormal … of the E3 ubiquitin ligase
of DAF-16, to disrupt ubiquitination, … and modulates longevity in Caenorhabditis elegans. Nat …